Our Science

Rigorous, robust, and transparent science is at the core of the development and assessment of our smoke-free products.

Smoke-free alternatives for adult smokers

Our scientific assessment is built on a collaborative approach and expertise in the fields of chemistry, biology, informatics, and medicine. Our practices are inspired by the pharmaceutical industry and FDA’s Draft Guidance for Modified Risk Tobacco Product Applications (2012).

Our product development process follows the principle of “Quality by Design.”
PMI’s toxicological assessment aims to confirm whether the reduced formation of harmful and potentially harmful constituents (HPHCs) leads to reduced toxicity in laboratory models.
Our clinical studies provide human data on the use and acceptance of our smoke-free products as well as their potential to reduce exposure to harmful chemicals and the potential to reduce the risk of smoking-related diseases as compared to continued smoking.
Understanding how our smoke-free products will be perceived and used.
The assessment of our smoke-free products continues after the products are placed on the market.
At each step, rigorous scientific standards are applied to generate data that evaluate whether smoke-free products reduce exposure to harmful and potentially harmful constituents or the risk of developing smoking-related diseases.